Titlebook: Resistance to Targeted Therapies in Multiple Myeloma; Silvia CW Ling,Steven Trieu Book 2021 Springer Nature Switzerland AG 2021 multiple m

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2196-5501 res chapters written by internationally-based leaders in the.Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many

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Mechanisms Driving Resistance to Proteasome Inhibitors Bortezomib, Carfilzomib, and Ixazomib in Mulecome a mainstay of myeloma therapy, significantly enhancing the overall survival of patients. However, bortezomib resistance continues to be a significant hurdle in the treatment of MM, despite the introduction of next-generation PIs such as carfilzomib and ixazomib. Unlike resistance to some other