Titlebook: Resistance to Targeted Therapies Against Adult Brain Cancers; Amanda Tivnan Book 2016 Springer International Publishing AG 2016 Brain canc

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Recurrence of Low-Grade Glioma: Have the Targeted Therapies Improved for Better Outcomes?,gical imaging to treatment planning has evolved. Nowadays, clinicians are leaning toward early surgical resection followed by adjuvant chemo- and/or radiotherapy rather than waiting for the tumor to recur before the treatment commences. This will put patients at risk of unavoidable treatment-related

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,Host–Tumor Interactions in Brain Cancer Metastasis Leading to Drug Resistance,deterioration, and reduced quality of life. At present, there are no targeted therapies solely for brain metastasis, and patients are more likely than not to be excluded from clinical trials evaluating new therapeutic agents. Treatment efforts are hindered by the blood-brain barrier, which prevents

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Recurrence of Low-Grade Glioma: Have the Targeted Therapies Improved for Better Outcomes?, side effects and increase of resistance to further treatment following tumor recurrence. The current chapter gives an overview of changes that have been made, together with limitations that we still encounter in managing patients with LGG in order to improve progression-free survival (PFS) and overall survival (OS).

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Book 2016er treatment. The volume will includeinformation on the repurposing of drugs in an attempt to circumventdrug resistance, use of small molecule inhibitors in GBM treatment,mechanisms of secondary brain metastasis, drug resistance, andstate-of-the-art imaging of targeted therapies..

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The Blood-Brain Barrier in Glioblastoma: Pathology and Therapeutic Implications,genetic and functional aspects of BBB function and dysfunction. Finally, the therapeutic implications of modulating BBB permeability and receptor-mediated transport will be discussed with a focus on chemotherapeutic drug delivery.

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