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Titlebook: Resistance to Photodynamic Therapy in Cancer; Valentina Rapozzi,Giulio Jori Book 2015 Springer International Publishing Switzerland 2015 P

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書目名稱Resistance to Photodynamic Therapy in Cancer
編輯Valentina Rapozzi,Giulio Jori
視頻videohttp://file.papertrans.cn/829/828456/828456.mp4
概述Explores mechanisms of action in PDT, the relationship between PDT cytotoxicity and cellular changes.Discusses the development of new technological advances in PDT for cancer.Offers strategic approach
叢書名稱Resistance to Targeted Anti-Cancer Therapeutics
圖書封面Titlebook: Resistance to Photodynamic Therapy in Cancer;  Valentina Rapozzi,Giulio Jori Book 2015 Springer International Publishing Switzerland 2015 P
描述This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches?to overcome resistance in tumor cells.
出版日期Book 2015
關(guān)鍵詞PDT; oxygen reactive species; photosensitizers; phototherapy and cancer; tumor cells; antibacterial drug
版次1
doihttps://doi.org/10.1007/978-3-319-12730-9
isbn_softcover978-3-319-38175-6
isbn_ebook978-3-319-12730-9Series ISSN 2196-5501 Series E-ISSN 2196-551X
issn_series 2196-5501
copyrightSpringer International Publishing Switzerland 2015
The information of publication is updating

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Tumor Microenvironment as a Determinant of Photodynamic Therapy Resistancetion status within the tumor, and expression and/or activation of proteins that mediate tumor progression can contribute to the efficacy of, or resistance to, various therapeutic modalities. Photodynamic therapy (PDT) is no exception—the oxygenation status and molecular makeup of the tumor and its s
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Isolation and Initial Characterization of Resistant Cells to Photodynamic Therapypotential mechanisms implicated in such resistance. In this sense, we describe the methods published for the isolation and characterization of tumor cells resistant to PDT. We also propose other unpublished procedures that could be of interest for the study of cells resistant to PDT. Factors such as
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GRP78-targeting Sensitizes Cancer Cells to Cytotoxic Effects of Photodynamic Therapyygen and reactive oxygen species. Intracellular proteins have been shown to undergo oxidation-related damage in response to PDT. A number of cytoprotective mechanisms have been demonstrated to relay on mechanisms associated with removal or re-folding of these proteins or leading to the induction of
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Optimization of Photodynamic Therapy Response by Survivin Genetional cancer therapies are based on targeting rapidly growing cancerous cells to block growth or enhance cell death, thereby, restoring the balance between these processes. In many instances, malignancies that develop resistance to current treatment modalities, for example photodynamic therapy (PDT
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Cellular Targets and Molecular Responses Associated with Photodynamic Therapyes associated with the use of PDT and we have observed increased expression of several prosurvival molecules that can modulate treatment efficacy. Specifically, angiogenic growth factors, inflammatory proteins, and anti-apoptotic molecules are often overexpressed following PDT-mediated oxidative str
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