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Titlebook: Resistance to Aromatase Inhibitors in Breast Cancer; Alexey Larionov Book 2015 Springer International Publishing Switzerland 2015 aromatas

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發(fā)表于 2025-3-21 16:15:34 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Resistance to Aromatase Inhibitors in Breast Cancer
編輯Alexey Larionov
視頻videohttp://file.papertrans.cn/829/828449/828449.mp4
概述Brings together the current knowledge of molecular and translational aspects of AIs resistance in breast cancer.Provides mechanisms of physiological resistance and potential biomarkers that recognize
叢書名稱Resistance to Targeted Anti-Cancer Therapeutics
圖書封面Titlebook: Resistance to Aromatase Inhibitors in Breast Cancer; Alexey Larionov Book 2015 Springer International Publishing Switzerland 2015 aromatas
描述Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients w
出版日期Book 2015
關(guān)鍵詞aromatase protein; breast cancer; estrogen receptor; genetic polymorphism; oestrogens; antibacterial drug
版次1
doihttps://doi.org/10.1007/978-3-319-17972-8
isbn_softcover978-3-319-38284-5
isbn_ebook978-3-319-17972-8Series ISSN 2196-5501 Series E-ISSN 2196-551X
issn_series 2196-5501
copyrightSpringer International Publishing Switzerland 2015
The information of publication is updating

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Raffaella Maria Gadaleta,Luca Magnaniunterricht in der Sekundarstufe.Hauptzielgruppe sind StudierIn diesem Buch werden wesentliche Fragen der elementaren Geometrie auf der Kugeloberfl?che und ihre Anwendungen auf die Erd- und Himmelskugel (mathematische Geografie und Astronomie) so aufgegriffen und beantwortet, dass sie als Hintergrund
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Abdul Aziz Bin Aiderus,Anita K. Dunbierunterricht in der Sekundarstufe.Hauptzielgruppe sind StudierIn diesem Buch werden wesentliche Fragen der elementaren Geometrie auf der Kugeloberfl?che und ihre Anwendungen auf die Erd- und Himmelskugel (mathematische Geografie und Astronomie) so aufgegriffen und beantwortet, dass sie als Hintergrund
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Structure, Regulation and Polymorphisms of the Aromatase Gene,ations of the aromatase gene and microRNA-mediated aromatase regulation may play a critical role in breast cancer progression. Several genetic polymorphisms in the aromatase gene may be prognostic factors of disease and may influence response to aromatase inhibitors.
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Ineffective Inhibition of Aromatase: A Cause for AI Resistance?,essing intratumour estrogen levels, they all point in the same direction; so far, there is no evidence indicating lack of tissue estrogen suppression among individual patients. Important, these findings do not exclude the possibility that in some patients intratumour aromatase to some degree may esc
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