Titlebook: Research in Attacks, Intrusions, and Defenses; 18th International S Herbert Bos,Fabian Monrose,Gregory Blanc Conference proceedings 2015 Sp

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Weixuan Mao,Zhongmin Cai,Don Towsley,Xiaohong Guancy. In recent years, the development of nonviral gene carriers has received great interest worldwide. However, the limitations of safety and low therapeutic efficacy make few nonviral gene vectors be used in clinical therapy of cancer. Therefore, co-delivery of functional genes and chemotherapeutic

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Thomas Kittel,Sebastian Vogl,Julian Kirsch,Claudia Eckertre are certain barriers in translating gene-based therapy to the clinical setting. For example, systemic delivery of genes into the brain is prevented by the blood–brain barrier (BBB); intraventricular delivery results in nonspecific distribution and gene expression; and stereotactic injection of ve

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st shown to be capable of enhancing transfer of RNA into mammalian cells in culture. Not only have other chemical methods been developed and refined, but also very efficient physical and viral delivery methods have been established. The technique of introducing DNA into cells has developed from tran

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Xiaokui Shu,Danfeng (Daphne) Yao,Barbara G. Rydersite of DNA vaccination (.). Despite these potential advantages for the delivery of DNA into the skin, a significant physical barrier impedes the transfer of large molecules, including DNA, into the epidermal cells. First, transdermal transport of molecules is limited by the low permeability of the

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Giancarlo Pellegrino,Constantin Tschürtz,Eric Bodden,Christian Rossowof DNA in vitro and in vivo (.-.). These nanoscopic polymers, characterized by regular dendritic branching, radial symmetry, and uniform size ranging from 4–11 nm, have excellent water solubility and biocompatibility in a broad range of concentrations. Nonmodified dendrimers have a high density of p