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Titlebook: Relaxing and Contracting Factors; Biological and Clini Paul M. Vanhoutte Book 1988 The Humana Press Inc. 1988 Dilatation.Drogen.blood vesse

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發(fā)表于 2025-3-21 18:46:59 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Relaxing and Contracting Factors
副標(biāo)題Biological and Clini
編輯Paul M. Vanhoutte
視頻videohttp://file.papertrans.cn/827/826311/826311.mp4
叢書名稱The Endothelium
圖書封面Titlebook: Relaxing and Contracting Factors; Biological and Clini Paul M. Vanhoutte Book 1988 The Humana Press Inc. 1988 Dilatation.Drogen.blood vesse
描述It is an exciting task to be the editor of the first monograph covering a new area of the biomedical sciences. Since the first report in 1980 by Robert Furchgott and colleagues (see Chapter 1) of the evidence of endothelium-dependent relaxation in isolated arteries, there are ever- increasing numbers of vascular physiologists and pharmacologists who are scraping away the endothelium to look into its role in cardiovascular con- trol. And the more one looks, the more one discovers. Not only is the list of substances that can induce endothelium-dependent relaxations im- pressively long, but these intriguing cells can also secrete vasoconstrictor substances. The ability of the endothelium to modulate the degree of con- traction of the underlying smooth muscle is an ancestral property of the blood vessel wall, illustrating the logic of nature, since the endothelial cells are located in the best possible strategic location to continuously monitor the properties (chemical or physical) of the blood. And more and more data emerge suggesting that in several cardiovascular diseases per- turbations in endothelium-dependent responses are one of the early signs of the abnormal process. Thus, the
出版日期Book 1988
關(guān)鍵詞Dilatation; Drogen; blood vessel; cardiovascular; cells; endothelium; hypertension; physiology; smooth muscl
版次1
doihttps://doi.org/10.1007/978-1-4612-4588-9
isbn_softcover978-1-4612-8939-5
isbn_ebook978-1-4612-4588-9
copyrightThe Humana Press Inc. 1988
The information of publication is updating

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The Nature of Endothelium-Derived Relaxing Factor,). Initial investigations into the mechanisms by which the phenomenon occurred suggested that it was mediated by a humoral agent, on the basis of “sandwich” experiments in which an aortic strip with intact endothelium could be shown to relax a closely apposed strip in which the endothelium had been
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Metabolism of Arachidonic Acid and Release of Endothelium-Derived Relaxing Factors, in vitro relaxation of vascular smooth muscle by acetylcholine. Subsequently, numerous other vasodilating substances have been found to have complete or partial endothelium dependence, and the term “endothelium-derived relaxing factor” (EDRF) was coined for the putative mediator of relaxation (Furc
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Release of Endothelium-Derived Relaxing Factor(s) by Physicochemical Stimuli, significant part, one would expect a continuous basal release of endothelium-derived vasoactive compounds, which would be effectively modulated or amplified by a number of physiological activators like metabolites, changes in PO. and PCO. (or pH), and similar parameters affected by increased activi
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in the best possible strategic location to continuously monitor the properties (chemical or physical) of the blood. And more and more data emerge suggesting that in several cardiovascular diseases per- turbations in endothelium-dependent responses are one of the early signs of the abnormal process. Thus, the978-1-4612-8939-5978-1-4612-4588-9
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T. M. Cocks,J. A. Angus,J. H. Campbell,G. R. Campbell
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