Titlebook: Relaxin and the Fine Structure of Proteins; Christian Schwabe,Erika E. Büllesbach Book 1998 Springer-Verlag Berlin Heidelberg 1998 Protein

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Introduction,iscovered the factor in 1925 in the serum of pregnant guinea pigs which, if injected into virgin guinea pigs, caused remodeling and widening of the symphysis pubis. Five years later Fevold et al demonstrated that the new factor was proteinaceous and that it could be isolated from ovaries.

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A Very Brief History, parturition. The discrepancy between the pelvic canal and the fetus in most mammals is so large and the pelvis so rigid that a special mechanism must exist which corrects this discrepancy if a species is to persist. Here is one of the few examples where biology has to submit to reason. The birth ca

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Other Mammalian and Chondrichtian Relaxins,years later,. and within another two years the sequence was published by John et a1.. The sequence was significantly different from that of porcine relaxin which was surprising in light of the similarity of rat and pig insulins. Variability proved to be the rule rather than the exception for relaxin

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Isolation and Sequence Analysis of Porcine Relaxin,kg of ovaries collected under contract in an abattoir had to be discarded because the collectors had ignored the order to do this rough measurement on the fetuses. A little inconvenience had turned them into endocrinologists which made them decide that the large yellow cysts that often occurred in p

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The Total Synthesis of Human Relaxin,l synthesis became the lesser problem. When a peptide chemist faces a new synthesis he will immediately divide the problem into two major categories, one the overall plan of development of a primary structure (fragment condensation versus synthesis by sequential addition of amino acids) and secondly

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