Titlebook: Regulation of microRNAs; Helge Gro?hans Book 2010 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Sci

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microRNA Biogenesis and Function,led to our current understanding of micro RNA biogenesis and function. this chapter is meant to provide a general overview of the various processes involved. for a comprehensive description of current models, I refer interested readers to the reviews and primary literature references provided in thi

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Stimulation of pri-miR-18a Processing by hnRNP A1,erved terminal loops, which are predicted to act as landing pads for trans-acting factors influencing miRNA processing. These results underscore a previously uncharacterized role for general RNA-binding proteins as factors that facilitate the processing of specific miRNAs, revealing an additional le

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Autoregulatory Mechanisms Controlling the Microprocessor,of the Microprocessor. These studies revealed that the Microprocessor is involved in the processing of the messenger RNA (mRNA) that encodes DGCR8. This regulatory feedback loop, along with the reported role played by DGCR8 in the stabilization of Drosha protein, is part of a newly identified regula

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Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression,is able to disengage miRNAs from the repressed mrNa, or render them inactive, provides evidence that miRNa regulation is much more dynamic then originally anticipated. In this chapter we review properties of HuR and describe examples of the cross-talk between the protein and miRNAs, with emphasis on

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MicroRNases and the Regulated Degradation of Mature Animal miRNAs,te (AGO) effector complexes, providing one possible mechanism that may control miRNA half-lives. We will summarize here what is known about miRNA turnover in animals and how recent discoveries have established a new dynamic of miRNA-mediated gene regulation. We will highlight some of the open questi

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Akiko Hata,Brandi N. DavisThe prolonged head-down position itself may lead to fatal outcome. The common features of such cases are as follows: . the finding of a body in an inverted or head-down tilted position; . marked (“monstrous”) congestion of face, scalp, neck, and other dependent parts of the body (e.g., hands, should