| 書目名稱 | Regulation of Membrane Na+-K+ ATPase |
| 編輯 | Sajal Chakraborti,Naranjan S Dhalla |
| 視頻video | http://file.papertrans.cn/826/825691/825691.mp4 |
| 概述 | A comprehensive investigation into the ATPase regulation of Membrane Na+-K+ ATPase.Explores the specific inhibitors and molecular probes for membrane ATPases to improve the therapy of various diseases |
| 叢書名稱 | Advances in Biochemistry in Health and Disease |
| 圖書封面 |  |
| 描述 | .Na.+.-K.+?.ATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s α- and β- subunits. At present four different α- (α-1,α-2,α-3 and α-4) and three β- (β-1, β-2, and β-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na.+.-K.+?.ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na.+.-K.+?.ATPase is either mediated by changes in intracellular Na.+.?concentrations that directly affect the Na.+.-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na.+.-K.+?.ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of α- and β- subunits leading to an increased expression in the level of Na.+.-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. T |
| 出版日期 | Book 2016 |
| 關鍵詞 | Membrane Na+-K+ ATPase; Cardiac Na+-K+ ATPase; Na+/K+-ATPase inhibitors; Na+-coupled cotransport; Na+-K+ |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-24750-2 |
| isbn_softcover | 978-3-319-79672-7 |
| isbn_ebook | 978-3-319-24750-2Series ISSN 2512-2142 Series E-ISSN 2512-2150 |
| issn_series | 2512-2142 |
| copyright | Springer International Publishing AG, part of Springer Nature 2016 |
|Archiver|手機版|小黑屋|
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