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Titlebook: Regulation of Alternative Splicing; Philippe Jeanteur Book 2003 Springer-Verlag Berlin Heidelberg 2003 Drosophila.Nucleotide.RNA.RNA Splic

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發(fā)表于 2025-3-21 16:46:04 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Regulation of Alternative Splicing
編輯Philippe Jeanteur
視頻videohttp://file.papertrans.cn/826/825651/825651.mp4
概述Excellent overview of alternative splicing.Incorporates newly emerging technologies and research directions.Includes supplementary material:
叢書名稱Progress in Molecular and Subcellular Biology
圖書封面Titlebook: Regulation of Alternative Splicing;  Philippe Jeanteur Book 2003 Springer-Verlag Berlin Heidelberg 2003 Drosophila.Nucleotide.RNA.RNA Splic
描述The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates
出版日期Book 2003
關(guān)鍵詞Drosophila; Nucleotide; RNA; RNA Splicing; Termination; biology; cellular processes; development; gene expre
版次1
doihttps://doi.org/10.1007/978-3-662-09728-1
isbn_softcover978-3-642-07858-3
isbn_ebook978-3-662-09728-1Series ISSN 0079-6484 Series E-ISSN 2197-8484
issn_series 0079-6484
copyrightSpringer-Verlag Berlin Heidelberg 2003
The information of publication is updating

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發(fā)表于 2025-3-21 20:42:08 | 只看該作者
https://doi.org/10.1007/978-3-662-09728-1Drosophila; Nucleotide; RNA; RNA Splicing; Termination; biology; cellular processes; development; gene expre
板凳
發(fā)表于 2025-3-22 00:31:55 | 只看該作者
地板
發(fā)表于 2025-3-22 06:35:49 | 只看該作者
Regulation of Alternative Splicing978-3-662-09728-1Series ISSN 0079-6484 Series E-ISSN 2197-8484
5#
發(fā)表于 2025-3-22 09:03:09 | 只看該作者
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發(fā)表于 2025-3-22 16:27:48 | 只看該作者
Prediction and Statistical Analysis of Alternatively Spliced Exons,can be found in these sequences by sequence comparison of genomic, mRNA and EST sequences. Furthermore, a large number of alternative exons have been described in the literature. Here, we review computer and manually curated databases of alternative exons and discuss the various approaches used to g
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發(fā)表于 2025-3-22 18:25:35 | 只看該作者
Multiple Roles of the SR Protein Family in Splicing Regulation,omain structure consisting of RNA binding and protein-protein interaction modules. SR proteins function as molecular adapters, mediating interactions between the pre-mRNA and the assembling spliceosome. Unlike most essential splicing factors, SR proteins have acquired an inherent flexibility that al
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發(fā)表于 2025-3-22 22:59:48 | 只看該作者
Heterogeneous Nuclear Ribonucleoprotein Particle A/B Proteins and the Control of Alternative SpliciMore than 25 different hnRNP proteins have been found associated with these complexes (Pi?ol-Roma et al. 1988; Dreyfuss et al. 1993). The core hnRNP proteins A1, A2, B1, B2, C1, and C2 are the most abundant species and are expressed in actively growing cells to levels that are comparable to core his
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發(fā)表于 2025-3-23 04:06:32 | 只看該作者
Phosphorylation-Dependent Control of the Pre-mRNA Splicing Machinery,e elucidation of mechanism(s) by which this modification alters the function of splicing factors. Phosphorylation has been implicated in the assembly of the spliceosome (Tazi et al. 1992; Mermoud et al. 1994a), regulation of splice site selection (Du et al. 1998; Xiao and Manley 1998; Prasad et al.
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發(fā)表于 2025-3-23 06:26:06 | 只看該作者
Splicing Regulation in , Sex Determination,ly .. The protein Sex-lethal acts as a master regulatory switch, being expressed exclusively in female flies and inducing female-specific patterns of alternative splicing on target genes. As a consequence, other regulatory factors are expressed in a sex-specific manner, and these factors control som
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