Titlebook: Redesigning the Molecules of Life; Conference Papers of Steven A. Benner Conference proceedings 1988 Springer-Verlag Berlin Heidelberg 1988

Embolism

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愉快么

e step further, to "control" the behavior of molecules by altering their structure in a controlled way. This is, in fact, a rather stringent definition of "understanding," as it requires the "prediction" of behavior from structure (or structure from behavior). But it also places technical demands on

FADE

Nicotinamide as a Coenzyme. An Evolutionary Model of Catalysis and Some Attempts to Translate Ideasicotinamide and related questions. One of us (C. M. V.) has approached bio-organic chemistry from an evolutionary standpoint. He has tried to devise a consistent picture of how bio-catalysis might have developed derived, at least in part, from analysis of possible relics of prebiotic chemistry in mo

ENACT

The Design of Peptides and Proteins Ranging from Hormones to Enzymes, we have focussed on designing and building model peptides where we could neglect tertiary structure in at least the early phases of our work. For many peptides and proteins that bind in the amphiphilic environments of biological interfaces, complementary amphiphilic secondary structures are induced

archenemy

不透氣

gangrene

embolus

Structure and Activity of Ribozymes,es to be quite informative. I will also discuss the use of nucleotide analogues and base modification procedures as structural probes. After briefly reviewing the other known and possible ribozymes, I will conclude with some speculative comments on the possibilities of making new enzymes, both from RNA and from novel ordered heteropolymers.

Curmudgeon

Judicious

Reconstructing the Evolution of Proteins,tion between selected and non-selected behaviors. We outline methods for constructing functional and historical models explaining these behaviors, and show how they can be applied to organizing biochemical data, tested experimentally, and used to engineer the behavior of proteins using recombinant DNA techniques.