Titlebook: Red Cell Shape; Physiology, Patholog Marcel Bessis,Robert I. Weed,Pierre F. Leblond Conference proceedings 1973 Masson & Cie, Editeurs, Par

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Conference proceedings 1973the shape, struc- ture, and functional characteristics of normal and pathologic erythrocytes. Most of the authors participated in a workshop on red cell shape held in June, 1972 at the Institute of Cell Pathology, Hopital de Bicetre, Paris. We hope that these various contributions on the physiology,

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Hemolysis, Induced by Pulsed Laser Irradiation, Transmitted along Rouleaux of Human Red Blood Cellse from a ruby laser. The target cell would lyse more rapidly if more energy was used in the laser pulse. Of particular interest was the observation that if a target cell was situated in a rouleau of cells then cells adjacent to the target cell would lyse as well.

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Erythrocyte Shape Alteration ? In Vitro ? : Relationship to Plasma and Cellular Factors Abstracteres after 36 hours (ATP <0.08 moles/ml). However, erythrocytes were largely (>75 %) discs at 18 hours and many were discoidal from 18 to 36 hours if examined in fresh plasma indicating a plasma factor in spherogenicity although injury does become irreversible.

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Membrane Fragmentation and Ca++-Membrane Interaction : Potential Mechanisms of Shape Change in the Sl erythrocyte’s life span is a function of time dependent changes of the erythrocyte which adversely affect its capacity to survive severe flow requirements of the microcirculation and the phagocytic elements of the reticuloendothelial system.

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Membrane Ultrastructure of Normal, Sickled and Heinz-Body Erythrocytes by Freeze-Etchingon, but permits morphologic identification of pathologic alterations in membrane structure at specific sites and surfaces. These observations provide added insight into membranogentic mechanisms of hemolytic anemias and structural membrane dynamics.

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Red Cell Biconcavity and Deformability A macromodel based on flow chamber observations been adequately explained by the theories and models proposed to date. Recent observations in a flow chamber have delineated additional characteristics of the red cell membrane which a model should satisfy. This communication describes both the flow chamber observations and a new macromodel of the red cell membrane.