Titlebook: Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology; Scientific and Clini Mohammad Resa Nowrousian Book 2008Latest edition Spring

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,Epoetin treatment of anemia associated with multiple myeloma and non-Hodgkin’s lymphoma,ssion after chemotherapy. However, it persists in patients who are unresponsive to treatment, and recurs in those with relapsing disease. Anemia is a general finding in later phases of the disease, when toxicity of long-term treatment, impairment of renal function, and heavy tumor load contribute to its induction and aggravation.

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Problems associated with erythropoietin receptor determination on tumor cells, vascular endothelium and malignant tumors) (.; .). This has led to the speculation that erythropoietin may have an additional pleiotropic role, eliciting a tissue protective response following ischemic stress or injury (.).

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Incidence and impact of anemia in radiation oncology,en anemia and decreased local control and survival in radiotherapy patients, some controversies have remained and a major issue of current research is whether or not the wellknown association between anemia and survival reflects a causal relationship or represents only an epi-phenomemon (.).