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Titlebook: Receptor/Ligand Sorting Along the Endocytic Pathway; Jennifer J. Linderman,Douglas A. Lauffenburger Book 1989 Springer-Verlag Berlin Heide

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書目名稱Receptor/Ligand Sorting Along the Endocytic Pathway
編輯Jennifer J. Linderman,Douglas A. Lauffenburger
視頻videohttp://file.papertrans.cn/824/823563/823563.mp4
叢書名稱Lecture Notes in Biomathematics
圖書封面Titlebook: Receptor/Ligand Sorting Along the Endocytic Pathway;  Jennifer J. Linderman,Douglas A. Lauffenburger Book 1989 Springer-Verlag Berlin Heide
描述This research monograph focuses on a biomolecular separation process that occurs within most cells. Two types of molecules, receptors and ligands, are separated and routed along different intracellular pathways; this is a critical step in the process of receptor-mediated endocytosis. The development of an understanding of the basic mechanisms of this separation process is presented, with an emphasis on discovering the fundamental and measurable parameters that influence the event. Mathematical models of sorting are evaluated to predict the range of possible outcomes. These are compared with a variety of experimental data on different receptor/ligand systems. In addition, the influence of the separation on overall receptor/ligand processing dynamics is discussed. The book is intended for both biomathematicians and biologists. It is not necessary to understand the details of the model equations and their solution in order to test the models experimentally. The analysis suggests experiments that might be done to further investigate the sorting process and the text details methods for analyzing these experimental results.
出版日期Book 1989
關(guān)鍵詞Mathematica; cell; cells; development; dynamics; experiment; influence; molecule; receptor; receptors; system
版次1
doihttps://doi.org/10.1007/978-3-642-48892-4
isbn_softcover978-3-540-50849-6
isbn_ebook978-3-642-48892-4Series ISSN 0341-633X Series E-ISSN 2196-9981
issn_series 0341-633X
copyrightSpringer-Verlag Berlin Heidelberg 1989
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Book 1989 separated and routed along different intracellular pathways; this is a critical step in the process of receptor-mediated endocytosis. The development of an understanding of the basic mechanisms of this separation process is presented, with an emphasis on discovering the fundamental and measurable p
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Introduction and Overview,immediate release to the environment, packaged into vesicles for later release to the environment upon the receipt of an appropriate stimulus, incorporated into the cell membrane or into organelle membranes, delivered to lysosomes to function there as enzymes, or delivered to other organelles. Molec
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Simple Kinetic Models of Sorting,n experimentally observed in several systems. In addition, this scheme does not allow for a variety of outcomes of the sorting process, as suggested by experimental data discussed later in this text (Chapters 5 and 6). Furthermore, it is not known whether the kinetics of ligand and receptor movement
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A Whole Cell Kinetic Model of the Endocytic Cycle: Focus on Sorting,e endosome. The most successful of these mechanisms, in terms of explaining the efficient recycling of receptors from the endosome back to the cell surface, suggested that receptors diffuse from the endosomal vesicles into tubules and are trapped there and that during this time ligand molecules equi
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