Titlebook: Receptor-Mediated Targeting of Drugs; G. Gregoriadis,G. Poste,A. Trouet Book 1984 Springer Science+Business Media New York 1984 biology.en

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Cabg318

Endocytosis of Liposomes and Intracellular Fate of Encapsulated Molecules: Strategies for Enhanced materials and deliver them, functionally intact, to particular in-vivo or in-vitro compartments. Liposomes are adaptable to the requirements of a wide range of experimental conditions, since it is possible to alter such parameters as liposome size, surface charge, bilayer fluidity, and stability. R

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The Use of Liposomes in Diagnostic Imaging,ructure. Using drug carriers the pharmacokinetics can be changed to make possible the selective drug delivery to normal and pathological tissues. Besides protecting the drug, the carrier facilitates the movement of the drug across anatomic and biochemical barriers to selected cells, tissues or organ

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Book 1984 or by their inability to interact with or reach target sites efficiently. New trends in pharmacology empha- size the development of methods for the optimization of drug action, for instance by the delivery of drugs, enzymes, hormones, antigens, genetic material, ets. through carrier systems selecti

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How do Protein Toxins Kill Cells?,ue to the fact that the active moieties of the toxins possess enzymatic activity. A single molecule may inactivate components required for protein synthesis more rapidly than the cell can produce new ones and hence kill the cell in the course of a few hours.

Agnosia

Significance of the Kinetics of Immunotoxin Cytotoxicity,m high to low potency depending on the antigen-immunotoxin (IT) system used. The advantage of the I-A-Ts is their low non-specific toxicity in-vivo (LD/50 in mice 20mg/kg),. which will allow their utilization in human patients in the near future.

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