Titlebook: Receptor-Mediated Targeting of Drugs; G. Gregoriadis,G. Poste,A. Trouet Book 1984 Springer Science+Business Media New York 1984 biology.en

即席演說

Study of the Transferrin Receptor Using a Cytotoxic Human Transferrin-Ricin a Chain Conjugate,ttachment of pure A chain to cell membranes has not been demonstrated (Raso, 1981), it is toxic at high concentrations indicating that cells can inefficiently internalize this 30,000 MW protein. Cytotoxicity is enhanced 10.–10.-fold however by recombining A chain either with its natural B chain subu

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How do Protein Toxins Kill Cells?,elated toxic proteins produced by bacteria and plants. The main reason why these toxins are used for this purpose is their extreme toxicity. This is due to the fact that the active moieties of the toxins possess enzymatic activity. A single molecule may inactivate components required for protein syn

BAIL

Emg827

Monoclonal Antibodies as Cell Targeted Carriers of Covalently and Non-Covalently Attached Toxins,rable interest because of its therapeutic potential. Intact plant or bacterial toxins linked to antibodies may acquire some cell selectivity but because toxin binding sites are retained, non-specific toxicity can still occur. Since the binding region of such toxins is distinct from the enzymatically

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Long-Term Kinetics of Antibody-Toxin Conjugates Show Resistant Cells, After this period, the surviving cells began growing again. The maximal rate of protein synthesis inactivation was one log inactivation each 10 h and was reached when the cell surface antigen was saturated with conjugate. Therefore, the maximal inactivation of one addition of conjugate over the 15

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Significance of the Kinetics of Immunotoxin Cytotoxicity, have been described by several laboratories as cytotoxic agents with high specificity for their target cells.. However, there was great variation from high to low potency depending on the antigen-immunotoxin (IT) system used. The advantage of the I-A-Ts is their low non-specific toxicity in-vivo (L

growth-factor

The Use of Ricin a Chain-Containing Immunotoxins to Kill Neoplastic B Cells,ts to apply this concept to the elimination of neoplastic and other target cells using antibodies coupled to toxic agents. A cell-binding antibody conjugated to a plant or bacterial toxin has been termed an “immunotoxin”. One such toxin, ricin, like most toxic proteins produced by bacteria and plant

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Selective Cytotoxicity of Ricin a Chain-Anti Carcinoembryonic Antibody Conjugates to Human Adenocartion antigens (1, 2) and immunoglobulin on the surface of murine and human B cell leukemia cells (3–6). We have recently explored this approach utilizing antibodies directed against the carcinoembryonic antigen, CEA (7–9), a well described tumor-associated antigen of adult human solid malignancies.

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Heretical

Fate of Liposomes In Vivo: Control Leading to Targeting,iculoendothelial system (RES). Rate of uptake in particular tissues of the RES depends on vesicle size, surface charge and lipid composition, amount of liposomal lipid given, animal species and physiological state. For instance, a large vesicle size and/or a negative surface charge promote rapid upt