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Titlebook: Recent Progress in the Genetic Epidemiology of Cancer; Henry T. Lynch (Professor of Medicine, Professor a Conference proceedings 1991 Spri

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發(fā)表于 2025-3-21 19:30:48 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書(shū)目名稱Recent Progress in the Genetic Epidemiology of Cancer
編輯Henry T. Lynch (Professor of Medicine, Professor a
視頻videohttp://file.papertrans.cn/824/823324/823324.mp4
圖書(shū)封面Titlebook: Recent Progress in the Genetic Epidemiology of Cancer; Henry T. Lynch (Professor of Medicine, Professor a Conference proceedings 1991 Spri
描述The discipline of genetic epidemiology pertains to the vertical transmission of the susceptibility (predisposition) to a complex disease in a structured population. This statement meets halfway 1 the broad definitiongiven by N. E. Morton and S. c. Chung in 1978 2 and the concise one given by M. -C. King et al. in 1984. 1t pinpoints the fundamental genetic hypothesis, namely, the existence of an inherited condition that predisposes an individual to a specific disease, and the corresponding subject ofinvestigation, the family. Thus, the genetic epidemiological situation consists of three basic elements: (l) the genealogical structure, (2) the mode of inherit- ance (i. e. , the "genetic model") for the trait of interest, and (3) the observable phenotypes of susceptibility. It is clear that genetic epidemiology is a research field posi- tioned at the intersection of molecular genetics, population gen- etics, and clinical genetics. Perhaps the genealogical tree should be its central element: it evidences something forgotten in mole- cular genetics, namely the relationships, and associations with probabilistic and statistical concepts from population genetics. It offers a structure and a
出版日期Conference proceedings 1991
關(guān)鍵詞Biostatistik; Cancer genetics; Chromosom; Genetik; Medizinische Informatik; Onkologische Epidemiologie; Re
版次1
doihttps://doi.org/10.1007/978-3-642-75993-2
isbn_softcover978-3-540-53022-0
isbn_ebook978-3-642-75993-2
copyrightSpringer-Verlag Berlin Heidelberg 1991
The information of publication is updating

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A Comprehensive Pedigree Analysis Tool: FAP (Family Analysis Package)f a disease, to test linkage, or to calculate risk factors for an individual, when it is known that a genetic disease is segregating within a family. Pedigree analysis unifies the approach to all three of these problems.
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https://doi.org/10.1007/978-3-642-75993-2Biostatistik; Cancer genetics; Chromosom; Genetik; Medizinische Informatik; Onkologische Epidemiologie; Re
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Genetic Epidemiology of RetinoblastomaThe retinoblastoma story provides a very good example of a case where mechanisms assessed by genetic epidemiology were confirmed several years later by molecular genetics. There are still some questions raised by the analysis of family data which remain unsolved and for which molecular genetic approaches will probably provide the expected answers.
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發(fā)表于 2025-3-23 05:08:14 | 只看該作者
Analysis of Association in Nuclear FamiliesThe major goal of association studies in genetics is to define risk haplotypes which may be responsible for the disease phenotype and to determine what kind of genetic control the marker system contributes to the disease, which may help then in better understanding the mode of inheritance for complex diseases.
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S. A. Seuchter,M. Knapp,M. P. Baur computing or intelligent technology. Some other branches have appeared recently like intelligent agents (which migrated from robotics to different engineering 978-3-7908-2506-0978-3-7908-1794-2Series ISSN 1434-9922 Series E-ISSN 1860-0808
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