書目名稱 | Recent Advances in Transthyretin Evolution, Structure and Biological Functions | 編輯 | Samantha J. Richardson,Vivian Cody | 視頻video | http://file.papertrans.cn/824/823039/823039.mp4 | 概述 | Transthyretin is a most exciting example for the study of the evolution of protein structure-function relationships.Covers both the basic and the clinical research into transthyretin.Brings the reader | 圖書封面 |  | 描述 | Since its ?rst description in 1942 in both serum and cerebrospinal ?uid, transthyretin (TTR) has had an eventful history, including changes in name from “prealbumin” to “thyroxine-binding prealbumin” to “transthyretin” as knowledge increased about its functions. TTR is synthesised in a wide range of tissues in humans and other eutherian mammals: the liver, choroid plexus (blood- cerebrospinal ?uid barrier), retinal pigment epithelium of the eye, pancreas, intestine and meninges. However, its sites of synthesis are more restricted in other vertebrates. This implies that the number of tissues synthesising TTR during vertebrate evolution has increased, and raises questions about the selection pressures governing TTR synthesis. TTR is most widely known as a distributor of thyroid hormones. In addition, TTR binds retinol-binding protein, which binds retinol. In this way, TTR is also involved with retinoid distribution. More recently, TTR has been demonstrated to bind a wide variety of endocrine disruptors including drugs, pollutants, industrial compounds, heavy metals, and some naturally occurring plant ?avonoids. These not only interfere with thyroid hormone delivery in the body, but a | 出版日期 | Book 2009 | 關(guān)鍵詞 | bacteria; biology; growth; hormone; mutation; neuropeptides; physiology; protein; protein structure; proteins | 版次 | 1 | doi | https://doi.org/10.1007/978-3-642-00646-3 | isbn_softcover | 978-3-642-42071-9 | isbn_ebook | 978-3-642-00646-3 | copyright | Springer-Verlag Berlin Heidelberg 2009 |
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書目名稱Recent Advances in Transthyretin Evolution, Structure and Biological Functions影響因子(影響力) 
書目名稱Recent Advances in Transthyretin Evolution, Structure and Biological Functions影響因子(影響力)學(xué)科排名 
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書目名稱Recent Advances in Transthyretin Evolution, Structure and Biological Functions被引頻次 
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書目名稱Recent Advances in Transthyretin Evolution, Structure and Biological Functions讀者反饋 
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