Titlebook: Recent Advances in Prolactin Research; Maria Diakonova, PhD Book 2015 The Editor(s) (if applicable) and The Author(s), under exclusive lic

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Prolactin-Induced Prostate Tumorigenesis,ors of the PRL signaling axis failed to identify an essential regulatory function on this tissue. However, a large body of evidence suggests an important role for PRL in prostate tumorigenesis. Mainly through the activation of its downstream target STAT5, PRL can induce growth and survival of prosta

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Prolactin in Inflammatory Response,pathways after binding to its receptor (PRLr) resulting in the activation of specific genes associated with the pleiotropic activities of PLR. To date, various PRLr isoforms have been described, generated by post-transcriptional or post-translational processes. PRL has been associated with the modul

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A Positive Feedback Loop Between Prolactin and Stat5 Promotes Angiogenesis,escribed that proangiogenic mediators such as fibroblast growth factors can activate members of the signal transducers and activators of transcription (STAT) family. STAT5 activation is necessary and sufficient to induce migration, invasion and tube formation of endothelial cells. STAT5 effects on e

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The Many Faces of Prolactin in Breast Cancer,gonist developed by introducing a single amino acid substitution mutation into human PRL (hPRL) at position 129, and a variety of G129R derivatives. The author has proposed two novel ideas for potential use of PRL, not anti-PRL agents, as an adjuvant agent for breast cancer, making it a hormone of many faces.

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Modeling Prolactin Actions in Breast Cancer In Vivo: Insights from the NRL-PRL Mouse,ndependent from ovarian steroids, and most are ER+. These characteristics resemble the human clinical disease, facilitating study of tumorigenesis, and identification of novel preventive and therapeutic approaches.

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Regulation of Blood Vessels by Prolactin and Vasoinhibins, efficient mechanism for controlling blood vessel growth and function. This review briefly describes the vascular actions of PRL and vasoinhibins, and addresses how their interplay could help drive biological effects of PRL in the context of health and disease.