Titlebook: Recent Advances in Cellular and Molecular Aspects of Angiotensin Receptors; Mohan K. Raizada,M. Ian Phillips,Colin Sumners Book 1996 The E

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Interactions of Angiotensin II with Central Dopamine,ure, and by modulating the release of pituitary hormones. Blood borne Ang II can access the brain via the circumventricular organs which have a permeable blood brain barrier. The central actions of Ang II in other brain regions beyond the blood brain barrier are probably mediated by Ang II synthesized within the brain (1,2).

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Human AT1 Receptor Gene Regulation,se through a pertussis toxin-sensitive G-protein (6). Given the diversity of AII-mediated events and the differential signal transduction mechanisms, it has been proposed that multiple AII receptor subtypes exist (1,7).

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AT1-Receptors and Cellular Actions of Angiotensin II in Neuronal Cultures of Stroke Prone-Spontaneoain neurons. In contrast, Ang II stimulation of PAI-1 mRNA in SP-SH neurons is only 50% that of in WKY rat brain neurons suggesting that SP-SH neurons express a decrease in AT.-receptor coupling with PAI-1 response. These observations demonstrate that SP-SH neurons express AT.-receptor-functions similar to those described for SHR neurons.

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