Titlebook: Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing; Hamed Alborzinia Book 2015 Springer Fachmedien Wiesbaden 2015 Biosensor C

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Introduction,oval for clinical application regarding drug safety and target efficacy (Marx and Sandig 2007). Any potential candidate compound must pass several phases of clinical testing (Fig. 1.1). A major approach has been to use laboratory animals or animal models, but the screening of thousands of novel comp

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Results,ing lowest in MCF-7 and highest in HCT-116; respiration being highest in MCF-7 and lowest in HT-29. Differences in glycolytic and respiratory activity may reflect variations in a cell’s ability to react to severe stress conditions. For instance, the lower basic glycolytic rate in MCF-7 cells may all

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Discussion,231, the two colorectal cancer cell lines HT-29 and HCT-116, and the liver hepatocellular carcinoma HepG2). In particular, there is a pronounced difference in the levels of glycolysis and respiration between MCF-7 (lowest acidification and highest respiration rates) and the other employed cell lines

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