Titlebook: Ras Superfamily Small G Proteins: Biology and Mechanisms 2; Transport Alfred Wittinghofer Book 2014 Springer International Publishing Switz

Irritate

BABY

沒(méi)花的是打擾

光亮

https://doi.org/10.1007/978-3-319-07761-1G-Protein effector-interactions; GTP binding; GTPase; intracellular transport; nucleo-cytoplasmic transp

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Effectors of Rab GTPases: Rab Binding Specificity and Their Role in Coordination of Rab Function andlity of the Rab proteins are crucial for their specificity..Rab:effector interactions exhibit a large diversity in binding affinities. The μM equilibrium dissociation constants (..s) of some complexes are most likely crucial for a fast regulation of Rab-regulated processes as they allow fast access

omnibus

A Rab Effector Called the Exocyst and Related Vesicle Tether Complexesing SNARE complex assembly in preparation for membrane fusion. Here, we will review in depth the first of these tethers, the exocyst complex that is required for the exocytic fusion of vesicles with the plasma membrane, and then discuss various parallels in both structure and function with the relat

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Rab GEFs and GAPs: The Enigma Variationscontrast, almost all known Rab GAPs possess a TBC1 domain. Here I will discuss the mechanisms by which these GEFs and GAPs regulate Rab GTPases, highlighting common themes and points of difference, and briefly outlining the cellular processes they regulate.

FOLLY

Arf Proteins and Their Regulators: At the Interface Between Membrane Lipids and the Protein Trafficklators outnumber their Arf substrates by at least 3-to-1, an important aspect of understanding Arf function is elucidating the mechanisms by which a single Arf protein is incorporated into different GEF, GAP, and effector complexes. New insights into these mechanisms have come from recent studies sh

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