Titlebook: Randomised Controlled Clinical Trials; Christopher J. Bulpitt Book 1983 Springer Science+Business Media Dordrecht 1983 experiment

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The Variability of Results,lity can be both estimated from its repeatability and reduced by quality control. The measurements may vary between subjects and this variability can be reduced by employing the within subject cross-over trial design. It must also be remembered that a measurement may be very repeatable but either no

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The Conduct of the Trial,are foreseen and taken account of prior to the start of the trial and those that are unexpected. Murphy’s law states, “If anything can go wrong it will.” This law has been attributed to captain E. Murphy, a development engineer, who applied it first to an individual technician saying, “If there is a

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Failure to Accept the Results of Randomised Controlled Trials, have been recruited; the treatment groups may not be identical in important respects; too few patients may have been recruited and the power of the trial may be too low; the results of the trial may not have been interpreted correctly; the trial result may not be consistent across different strata