Titlebook: RNA Structure and Function; Jan Barciszewski Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springe

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Detection of RNA Structure and Interactions Using Nanopore Technology,ion transfer and decoding, splicing, transcriptional regulation and translation. These vital processes are in large part determined by the complex structures and modular folding adopted by RNA. Nanopore technology has emerged as a powerful technique to interrogate native RNA directly at the single m

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,Mapping In Situ RNA–RNA Interactions with RIC-seq,s through complementary base pairing with the help of proteins. Mapping of intra- and inter-molecular RNA–RNA interactions (RRIs) is required to unravel the structure and targets of ncRNAs which are two essential aspects for understanding the molecular mechanisms of ncRNAs in various biological proc

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Structured RNAs and Their Role in Biology and Therapeutics,les of structured RNAs, functional RNA sequences with 3D structures. In this chapter, we will discuss the structural features of hammerhead, hairpin,?., and twister small self-cleaving ribozymes that are relevant for their biological function, and specific biochemical studies that help elucidate the

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Probing the RNA Structure-Dependent RNA Regulations and Functions, factors. Latest technological innovations have allowed us to detect RNA structures on a large scale with recent analyses of RNA structure revealing how dynamic RNA structures mediate RNA regulatory functions. In this chapter, we review the latest technological advances in RNA structure probing and

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Probing Techniques of Secondary and Tertiary RNA Structure and a Case Study for RNA G-Quadruplexes, the analysis of RNA structure is essential to understand the cellular roles of distinct RNA molecules. Technical approaches used to study RNA structure comprise bioinformatics tools, structural probing, and biophysical methods to integrate sequence and 3D structure information. In this review, I fo

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Structure and Folding Patterns of RNA G-Quadruplexes,to take part in a wide range of cellular events such as telomere maintenance, gene expression mechanisms, etc. RNA G-quadruplex is found to be present in a significant portion of the non-coding transcriptome, thus acting as a biomarker for several diseases. RNA quadruplex is also shown to be associa

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