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Titlebook: Quantitative Aspects of Allosteric Mechanisms; Alexander Levitzki Book 1978 Springer-Verlag Berlin · Heidelberg 1978 Allosterie.Cooperativ

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書目名稱Quantitative Aspects of Allosteric Mechanisms
編輯Alexander Levitzki
視頻videohttp://file.papertrans.cn/781/780797/780797.mp4
叢書名稱Molecular Biology, Biochemistry and Biophysics‘ Molekularbiologie, Biochemie und Biophysik
圖書封面Titlebook: Quantitative Aspects of Allosteric Mechanisms;  Alexander Levitzki Book 1978 Springer-Verlag Berlin · Heidelberg 1978 Allosterie.Cooperativ
描述The aim of this monograph is to summarize the essential features which characterize the behavior of regulatory systems. Firstly we discuss the laws which govern ligand binding in thermodynamic terms. The basic cooperative and allosteric phenomena are des- cribed in thermodynamic terms without assuming any particular mo- del. Then the molecular models developed by Monod, Wyman and Changeux and by Koshland, Nemethy and Filmer are presented in detail. Special emphasis has been given to the analysis of the Hill coefficient and its meaning both in thermodynamic terms and in terms of the two allosteric models: the concerted model of Monod, Wyman and Changeux and the sequential model of Koshland, Nemethy and Filmer. Special types of cooperativities are dis- cussed in some detail namely, cooperativity stemming from ligand- coupled protein association or dissociation, negative cooperati- vity and half-of-the-sites reactivity. A slightly extended space was devoted to the discussion of negative cooperativity and half- of-the-sites reactivity, since the existence of these phenomena and their possible biological importance is less of a common knowledge than positive cooperativity. This monograp
出版日期Book 1978
關(guān)鍵詞Allosterie; Cooperativity; Enzym; Kooperativit?t (Biochem; ); Regulation; behavior; biology; enzyme; enzymes;
版次1
doihttps://doi.org/10.1007/978-3-642-81231-6
isbn_softcover978-3-642-81233-0
isbn_ebook978-3-642-81231-6Series ISSN 0077-0221
issn_series 0077-0221
copyrightSpringer-Verlag Berlin · Heidelberg 1978
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Alexander Levitzkindividuals (See, for example, Miller, 1982; Inglis and Stromback, 1984; Wooden et al, 1984; Chapman and Miller, 1985; Wooden and Robertson, 1989; Foster et al, 1991; Beggs and Chapman, 1990; Chapman and Salvage, 1994; Cobb-Clark and Chapman, 1999; Le and Miller, 2000). All invariably show that emplo
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Alexander Levitzkinsfers. It is necessary first, however, to look a little more carefully into the welfare implications of logrolling. I should say here, for the benefit of those interested in income transfers who are not accustomed to economic reasoning and to particular economic applications in political problems,
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The Structure of Multisubunit Proteins,ract with each other by way of specific noncovalent bonds. The subunits always form a well-defined geometrical structure, and the architecture obtained determines to a large extent the regulatory properties of the protein. It will therefore be necessary for us to discuss in some detail the principles of design of oligomeric proteins.
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