Titlebook: pKa Prediction for Organic Acids and Bases; D. D. Perrin,Boyd Dempsey,E. P. Serjeant Book 1981 D. D. Perrin, Boyd Dempsey and E. P. Serjea

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Prediction of p,, Values for Phenols, Aromatic Carboxylic Acids and Aromatic Amines,Within any class of substituted aromatic acid or base it is usually found that the acidic dissociation constant will vary in much the same way as that of the corresponding derivative in any other class. In most cases, these changes in acid strength, ?p.., produced by a substituent in a .- or .-position can be predicted by the Hammett equation.

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Examples where Prediction Presents Difficulties,It is important to recognize limitations to the possibility of predictions and to be on the alert for methods by which these inadequacies can be identified. This is often possible if data on appropriate model compounds are available.

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Introduction,many of the p.. values which express the strengths of organic acids and bases. This book seeks to provide guidelines to enable such predictions to be made, illustrating the methods used and giving numerous worked examples.