| 書目名稱 | Purine Metabolism in Man | | 副標(biāo)題 | Enzymes and Metaboli | | 編輯 | Oded Sperling,Andre Vries,James B. Wyngaarden | | 視頻video | http://file.papertrans.cn/765/764093/764093.mp4 | | 叢書名稱 | Advances in Experimental Medicine and Biology | | 圖書封面 |  | | 描述 | Gout and uric acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of uric acid excretion, although still posing difficult problems, appears to approach clari- fication. | | 出版日期 | Book 1974 | | 關(guān)鍵詞 | Purine; enzymes; metabolism; mutation; synthesis | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4684-3294-7 | | isbn_softcover | 978-1-4684-3296-1 | | isbn_ebook | 978-1-4684-3294-7Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
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