| 書目名稱 | Protein Metabolism and Homeostasis in Aging | | 編輯 | Nektarios Tavernarakis | | 視頻video | http://file.papertrans.cn/762/761704/761704.mp4 | | 概述 | Illustrates that aging cells are characterized by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation is controlled at multiple levels.Di | | 叢書名稱 | Advances in Experimental Medicine and Biology | | 圖書封面 |  | | 描述 | Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data. Protein turnover, the balance between protein synthesis and protein degradation are carefully maintained in healthy cells. Chapters 1 and 2 illustrate that aging cells are characterised by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation, essential for cell growth and survival, is controlled a | | 出版日期 | Book 2010 | | 關鍵詞 | Aging; Homeostasis; Metabolism; Protein; Tavernarakis; insulin; signal transduction | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4419-7002-2 | | isbn_softcover | 978-1-4899-7939-1 | | isbn_ebook | 978-1-4419-7002-2Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
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