| 書目名稱 | Proteases and Cancer | | 副標(biāo)題 | Methods and Protocol | | 編輯 | Thomas H. Bugge,Toni M. Antalis | | 視頻video | http://file.papertrans.cn/762/761549/761549.mp4 | | 概述 | Presents cutting-edge technologies for the analysis of protease activity, function and substrate detection.Contains step-by-step methods and examples.Details a wide range of complementary techniques f | | 叢書名稱 | Methods in Molecular Biology | | 圖書封面 |  | | 描述 | .Proteases decisively contribute to cancer development and promotion by regulating the activities of growth factors/cytokines and signaling receptors, as well as the composition of the extracellular matrix, thereby suppressing cell death pathways and activating cell survival pathways. In .Proteases and Cancer: Methods and Protocols., expert researchers bring together a wide range of current, complimentary techniques that have been developed for the specific detection and analysis of proteases and their activities in cancer biology. The volume covers vital topics including the application of proteomics technologies for the detection of protease expression in tumors, imaging proteases by activity profiling, proteomics technologies for the identification of biological substrates, detection of cell surface proteolysis, imaging of protease activity, the use of transgenic mice to determine protease function in tumor initiation and progression, and the development of anti-protease therapies for cancer. Written in the highly successful .Methods in Molecular Biology.? series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, ste | | 出版日期 | Book 2009 | | 關(guān)鍵詞 | Cancer development; Protein cleavage; Proteolytic enzymes; Tumor cells; imaging; tissue | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-60327-003-8 | | isbn_softcover | 978-1-62703-944-4 | | isbn_ebook | 978-1-60327-003-8Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2009 |
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