| 書(shū)目名稱 | Preparative Polar Organometallic Chemistry | | 副標(biāo)題 | Volume 1 | | 編輯 | Lambert Brandsma,Hermann D. Verkruijsse | | 視頻video | http://file.papertrans.cn/755/754811/754811.mp4 | | 圖書(shū)封面 |  | | 描述 | Polar organometallic compounds are indispensable for the synthetic chemist. As this book shows, these almost ideal reagents are easy to prepare with high specificity under mild conditions and yet react quite readily with a great variety of substrates. Many compounds can be metallated directly at positions which would otherwise be difficult to substitute. Functional groups and heteroatoms already present in a molecule direct metallation to sites in their vicinity. The rules which govern polar organometallic chemistry often are not dominated by the usual n-delocalization and inductive effects; dipolar interactions, chelation, polarization, etc. often can be much more important. This affords novel synthetic opportunities. A good example is the development of a basically new type of aromatic substitution chemistry not based on positively charged intermediates. Seebach‘s injunction, "Thinking of polar organometallic compounds as carbanions is an impoverishment rather than a simplification" (International Symposium, Chemistry of Carbanions, Durham 1984), stresses the need to consider the metal not only as an integral, but perhaps also as the key component of these reagents. Rather than w | | 出版日期 | Textbook 1987 | | 關(guān)鍵詞 | Organometallic chemistry; carbon; organic synthesis; synthesis | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-87921-0 | | isbn_softcover | 978-3-540-16916-1 | | isbn_ebook | 978-3-642-87921-0 | | copyright | Springer-Verlag Berlin Heidelberg 1987 |
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