| 書(shū)目名稱 | Phosphoinositides I: Enzymes of Synthesis and Degradation | | 編輯 | Tamas Balla,Matthias Wymann,John D. York | | 視頻video | http://file.papertrans.cn/747/746355/746355.mp4 | | 概述 | In depth discussion of the state of the art of phosphoinositide research.Experts in the field discussing the ‘hot‘ topics in phosphoinositide research.A volume dedicated to the enzymes involved in the | | 叢書(shū)名稱 | Subcellular Biochemistry | | 圖書(shū)封面 |  | | 描述 | Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impr | | 出版日期 | Book 2012 | | 關(guān)鍵詞 | PI 3-kinase; PTEN; kinase; phosphatase; phosphoinositide | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-007-3012-0 | | isbn_softcover | 978-94-017-8157-2 | | isbn_ebook | 978-94-007-3012-0Series ISSN 0306-0225 Series E-ISSN 2542-8810 | | issn_series | 0306-0225 | | copyright | Springer Science+Business Media B.V. 2012 |
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