| 書目名稱 | Pharmacokinetic-Pharmacodynamic Modeling and Simulation | | 編輯 | Peter L. Bonate | | 視頻video | http://file.papertrans.cn/746/745579/745579.mp4 | | 概述 | There is no integrated book on pharmacokinetic-pharmacodynamic modeling that deals with the process of modeling or provides the necessary level of detail to train new modelers..There is a dearth of ph | | 圖書封面 |  | | 描述 | .A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops in that manner – each chapter builds upon previous chapters by first presenting the theory and then illustrating the theory using published data sets and actual data sets that were used in the development of new chemical entities collected by the author during his years in industry. A key feature of the book is the process of modeling. Most books and manuscripts often present the final model never showing how the model evolved. In this book all examples are presented in an evolutionary manner.. | | 出版日期 | Book 20061st edition | | 關鍵詞 | development; evolution; pharmacodynamics; pharmacokinetics; population; simulation | | 版次 | 1 | | doi | https://doi.org/10.1007/b138744 | | isbn_ebook | 978-0-387-27199-6 | | copyright | Springer-Verlag US 2006 |
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