| 書目名稱 | Peptides in Oncology I | | 副標(biāo)題 | LH-RH Agonists and A | | 編輯 | K. H?ffken | | 視頻video | http://file.papertrans.cn/744/743550/743550.mp4 | | 叢書名稱 | Recent Results in Cancer Research | | 圖書封面 |  | | 描述 | Hormonal treatment of malignant diseases has been used for quite some years now, and progress in this field is still being made at a steady pace. The detection of new endocrine feed- back loops and the availability of new classes of hormonal agents made hormonal intervention with predictable outcome possible. Besides the intellectual challenge of modulating the hormone system, an important aspect of recent research on hormones and cancer is the reduction of treatment-related morbidity achieved with the new hormonal strategies. Thus, controlled intervention in the hypothalamic-gonadotropic axis is increasingly apt to replace surgical removal of the relevant glands, i. e. , the pituitary gland or the gonads. In the same way as, for example, aromatase inhibitors are being used as a substitute for adrenalectomy. The concept that secretion of hypothalamic gonadotropin- releasing hormone (GnRH), pituitary gonadotropins, and sex steroids are regulated via negative and positive feedback loops is based on the pioneering work of Hohlweg and Harris some 40 years ago. In 1971, a breakthrough was achieved with the isolation, structural analysis, and synthesis of the luteinizing hormone releasin | | 出版日期 | Book 1992 | | 關(guān)鍵詞 | breast cancer; cancer; hormones; oncology; ovarian cancer; pancreatic cancer; prostate cancer | | 版次 | 1 | | doi | https://doi.org/10.1007/978-88-470-2186-0 | | isbn_softcover | 978-88-470-2188-4 | | isbn_ebook | 978-88-470-2186-0Series ISSN 0080-0015 Series E-ISSN 2197-6767 | | issn_series | 0080-0015 | | copyright | Springer-Verlag Berlin Heidelberg 1992 |
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