| 書目名稱 | Pathology of Septic Shock | | 編輯 | E. T. Rietschel,Hermann Wagner | | 視頻video | http://file.papertrans.cn/743/742275/742275.mp4 | | 叢書名稱 | Current Topics in Microbiology and Immunology | | 圖書封面 |  | | 描述 | Severe sepsis and septic shock are the most serious compli- cations of bacterial infections. Both gram-positive and gram- negative bacteria can trigger these extreme inflammatory re- sponses and, by so doing, cause substantial morbidity and mortality. In the United States alone, over 400 000 patients suffer from septicaemia each year, and approximately 100 000 of these patients die despite optimal intensive care and modern antimicrobial therapy. These dramatic figures have prompted intensive research to define the bacterial and host factors involved in the septic response. Scientists from many disciplines, including chem- istry, physics, biology, medical microbiology, immunology, and pharmacology, have worked closely with clinicians to achieve rapid and profound progress. To translate this newly acquired knowledge into clinical practice, clinical trials have also been performed to evaluate numerous new therapeutic drugs. The disappointing results from these trials have underscored a major lesson, namely, that sepsis constitutes an extremely complex syndrome and that basic and clinical research must be greatly intensified in order to illuminate its molecular mechan- isms. At this st | | 出版日期 | Book 1996 | | 關(guān)鍵詞 | Activation; Antigen; Endotoxin; Lipopolysaccaride; Signal pathways; bacteria; cytokine; immune system; immun | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-80186-0 | | isbn_softcover | 978-3-642-80188-4 | | isbn_ebook | 978-3-642-80186-0Series ISSN 0070-217X Series E-ISSN 2196-9965 | | issn_series | 0070-217X | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
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