| 書目名稱 | Patho-Epigenetics of Disease | | 編輯 | Janos Minarovits,Hans Helmut Niller | | 視頻video | http://file.papertrans.cn/743/742072/742072.mp4 | | 概述 | Patho-Epigenetics is a new discipline, and it’s covered here in detail.Written by experts in this exciting new field.Brings together recent results of epigenetic research with special attention to dis | | 圖書封面 |  | | 描述 | .In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences..Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity. .An alternative system of .epigenetic memory., the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression .via .modification of histone tails. .The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transm | | 出版日期 | Book 2012 | | 關(guān)鍵詞 | infectious diseases | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4614-3345-3 | | isbn_softcover | 978-1-4899-9178-2 | | isbn_ebook | 978-1-4614-3345-3 | | copyright | Springer Science+Business Media New York 2012 |
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