Titlebook: Oxygen Transport to Tissue XXVI; Paul Okunieff,Jacqueline Williams,Yuhchyau Chen Conference proceedings 2005 The Editor(s) (if applicable)

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Simulation Study of Breast Tissue Hemodynamics During Pressure Perturbation,on during breast examination impact on the circulatory systems of the breast tissue, namely blood flow, blood pooling, and oxygen concentration? We assumed that the blood was distributed in two compartments, arterial and venous. All the parameters were expressed with oxy- and deoxyhemoglobin quantit

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Microvascular Oxygenation and Oxidative Stress During Postischemic Reperfusion,n microvessels and tissue and oxidant stress during postischemic reperfusion in hamster cheek pouch microcirculation. We measured PO. by using phosphorescence quenching microscopy and oxygen radical species (ROS) production in the systemic blood. We evaluated the effects of a NOS inhibitor (L-NMMA)

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Hypoxia, Tumor Endothelium, and Targets for Therapy,n various organs/tissues in the same patient, or the same tumor cells implanted in different sites or organs in the preclinical host, have different levels of hypoxia and different levels of response to systemic therapies. Over the past 10 years, it has been established that normal cells involved in

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Genetic Oxygen Sensor,n expression vector, pCMX-GFP, using a polyethylenimine reagent and cultured for 48 hrs. After exposure of the cell to anoxic gas (O.<.001%), a 1 min illumination of the cell to strong 470–490 nm light evoked a significant red fluorescence (excitation 520–550 nm, emission >580 nm) that had been negl

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Effects of Insulin and Catecholamines on Inotropy and Oxygen Uptake, VO.), and oxygen consumption at rest (resting VO.) in . isolated canine gastrocnemius-plantaris muscle. Rejuvenated red cells suspended in perfusate at hematocrit 30% and 45%, perfusate contained insulin (100 μU·ml.), adrenalin (0.3 and 3 ng·ml.), and noradrenaline (3 ng·ml.). Insulin significantly

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Adaptation to Chronic Hypoxia During Diet-Induced Ketosis,g starvation or diet, resulting in increased plasma ketones (acetoacetate + β-hydroxybutyrate; BHB). We investigated glucose and lactate adaptation to hypoxia in concurrence with diet-induced ketosis. Male Wistar rats were fed standard (STD), ketogenic (high fat; KG), or carbohydrate-rich (low fat;

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Varied Response of Spontaneous Tumors to Antiangiogenic Agents,etrimental effects on tumor vascular function, thus compromising combination therapies. A second question is whether experimental results based on fast-growing, transplanted tumors mimic those in slowly developing spontaneous tumors, which may be more representative of response in human primary tumo

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Non-Invasive Measurement of Tumor Oxygenation Using Embedded Microparticulate EPR Spin Probe, using embedded paramagnetic particulates. The new approach uses spin probes that are permanently embedded or implanted in the tumor. A particular advantage of this procedure is that it is non-invasive, both in terms of implantation of the probe as well as readouts of oxygen. We implanted a mixture

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Hyperthermia and Hypermetabolism in Focal Cerebral Ischemia,wed that occlusion of the posterior cerebral artery (PCA), middle cerebral artery (MCA), and the contralateral anterior cerebral artery (ACA) created a large cortical and subcortical stroke in the non-human primate (NHP). Subsequently, we created the same stroke endovascularly in the NHP. Using the