Titlebook: Oxygen Sensing; Molecule to Man Sukhamay Lahiri,Naduri R. Prabhakar,Robert E. Fors Book 2002 The Editor(s) (if applicable) and The Author(s

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A Genomic Model for Differential Hypoxic Ventilatory Responses57BL/6J (B6) inbred mice also demonstrate a significantly different ventilatory pattern during acute hypoxic challenge. The present study rejects the hypothesis that a genomic basis for differential hypoxic ventilatory responses (HVR) is linked to loci which determine differential breathing pattern

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Regulation of the Hypoxia-Inducible Factor-1αbon receptor nuclear translocator (ARNT). Whereas hypoxia prevents ubiquitination and proteasomal degradation of HIF-1α ARNT expression is thought to be oxygen-independent. We and others previously showed that ARNT is indispensable for HIF-1 DNA-binding and transactivation function. To examine the r

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Hypoxia-Induced Regulation of mRNA Stabilityt for oxygen, all higher organisms have evolved numerous diversely regulated mechanisms to detect and respond to potentially life-threatening occurrences of decreased oxygen availability (hypoxia). While the oxygen-dependent regulation of gene expression involves both transcriptional- and post-trans

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Hypoxia, HIF-1, and the Pathophysiologi of Common Human Diseasesdisease, and congestive heart failure. In these disease states, hypoxia induces changes in gene expression in target organs that either fail to result in adequate adaptation or directly contribute to disease pathogenesis. Hypoxia-induciblc factor I (HIF-1) is a transcriptional activator that is expr

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Regulation of Creb by Moderate Hypoxia in PC12 Cellsn the cyclic AMP response element binding protein (CREB) transcription factor. PC 12 cells were exposed to moderate levels of hypoxia (5% O.) for various times between 20 min and 6 hr. We found that hypoxia rapidly and persistently induced ser. phosphorylation of CREB. This effect was more robust th

Initial

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Rox1 Medited Repression biosynthesis. Heme induces the transcription of oxygen-induced genes and represses the transcription of hypoxic genes. Repression is mediated by the Rox1 protein in conjunction with the Ssn6/Tupl general repression complex. The differential repression of hypoxic genes results from a combination of

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oyed as an embedded cultural advisor.Offers detailed observa.?This book focuses on the war in Afghanistan. In 2010 and 2011, the author took a leave from her faculty position at the University of California, Irvine to train and then deploy as a cultural advisor with two U.S. Army combat units in Afg