Titlebook: Oxygen Radicals in the Pathophysiology of Heart Disease; Pawan K. Singal Book 1988 Kluwer Academic Publishers 1988 cardiovascular.cardiova

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Alterations in Membrane Phospholipids, Mechanisms of Free Radical Damage and Antioxidant Protectionf free radical-mediated myocardial damage also will be reviewed. Free radicals have the potential to initiate peroxidation of membrane phospholipids and may cause extensive membrane damage contributing to the development of irreversible myocardial injury.

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Importance of Electron Transfer through Allopurinol in Protection from Reperfusion Injury, source of these radicals. However, other interpretations could be drawn from this data. Using the heart as a focus of discussion, we shall study another possible effect of the most widely used xanthine oxidase inhibitor, allopurinol.

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The Role of Lipid Peroxidation in the Myocardium in Stress and Antioxidant Protection of the Heart,genesis of stress-induced damage of the heart and possibilities of its antioxidant protection constitute one of essential problems of current cardiology. This problem has been discussed in recent works (9,11), however, a number of questions remains still open.

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Do Free Radicals Contribute to the Genesis of Reperfusion-Induced Arrhythmias?,It is now well established that occlusion of a major coronary artery for a relatively short duration, followed by abrupt reperfusion can lead to severe ventricular arrhythmias (see Figure 1).

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Role of Antioxidants in Hypoxia-Reoxygenation Injury in the Heart and in Cardiac Myocytes,The studies initiated by our group (1–5) and others (6,7) in order to elucidate the effect of α-tocopherol on heart function have stimulated further investigations in order to clarify, in this muscle, the role of antioxidants in the prevention of the peroxidation of polyunsaturated fatty acids and in the stabilization of the biological membranes.

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https://doi.org/10.1007/978-1-4613-1743-2cardiovascular; cardiovascular system; cell; heart; lipide; metabolism; pathophysiology; physiology; researc