| 書目名稱 | Osteosarcoma | | 編輯 | Takafumi Ueda,Akira Kawai | | 視頻video | http://file.papertrans.cn/705/704943/704943.mp4 | | 概述 | Provides valuable descriptions of an important new treatment for osteosarcoma.Reviews the outstanding advances made in clinical outcomes for osteosarcoma over the past three decades.Presents a multidi | | 圖書封面 |  | | 描述 | This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressive management of pulmonary metastasis. Osteosarcoma was a miserable disease for adolescents and young adults until the early 1970s, with a survival rate that was less than 10–15% even after amputation for affected limbs because of the progression of pulmonary metastasis. With the development of neoadjuvant chemotherapy for osteosarcoma, including high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide during the late 1970s and the 1980s, however, the prognosis has dramatically improved. Limb-salvage surgery for patients with extremity osteosarcoma is now a gold-standard surgical procedure for more than 90% of patients with localized disease. Additionally, aggressive pulmonary metastasectomy for patients with lung metastasis fromosteosarcoma has contributed to improvement of their survival. More recently, carbon-ion radiotherapy has also been introduced for patients with unresectable osteosarcoma of the trunk, as in the spine | | 出版日期 | Book 2016 | | 關(guān)鍵詞 | doxorubicin; ifosfamide; limb-salvage surgery; methotrexate; neoadjuvant chemotherapy; pulmonary metastas | | 版次 | 1 | | doi | https://doi.org/10.1007/978-4-431-55696-1 | | isbn_softcover | 978-4-431-56677-9 | | isbn_ebook | 978-4-431-55696-1 | | copyright | Springer Japan 2016 |
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