Titlebook: Osteoimmunology; Yongwon Choi Conference proceedings 2007 The Editor(s) (if applicable) and The Author(s), under exclusive license to Spri

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Schnurri-3: A Key Regulator of Postnatal Skeletal Remodeling,hn3 display an osteosclerotic phenotype with profoundly increased bone mass due to augmented osteoblast activity. Shn3 controls protein levels of Runx2, the principal regulator of osteoblast differentiation, by promoting its degradation. In osteoblasts, Shn3 functions as a component of a trimeric co

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The Negative Role of IDS in Osteoclastogenesis,mmon progenitor with macrophages and dendritic cells (DCs). Two essential cytokines, macrophage colony-stimulating factor (M-CSF) and TRANCE (also called RANKL, OPGL, and ODF), enable osteoclast differentiation from their monocyte/macrophage lineage precursors (Suda, Takahashi, Udagawa, et al. 1999;

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Regulation of Hematopoietic Stem Cells in the Osteoblastic Niche,es enable stem cells to play a central role in maintaining tissues. Many adult tissue stem cells, including hematopoietic system, skin epidermis, gastrointestinal epithelium, brain, and lung were identified (Fuchs, Tumbar, and Guasch 2004; Moore and Lemischka 2006). The activity of tissue stem cells

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