Titlebook: Osteochondral Tissue Engineering; Nanotechnology, Scaf J. Miguel Oliveira,Sandra Pina,Julio San Roman Book 2018 Springer International Publ

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Micro/Nano Scaffolds for Osteochondral Tissue Engineeringracellular matrix. The structure and gradients of organic and inorganic components present in the cartilage and bone tissues must be considered together. Another critical aspect is an efficient interface between both tissues. So far, most of the approaches were focused on the development of multilay

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Mimetic Hierarchical Approaches for Osteochondral Tissue Engineerings the interface between them, in effect mimicking the developmental processes when generating hierarchical scaffolds that show gradual changes of physical and mechanical properties, ideally complemented with the biochemical gradients. There are several components whose characteristics need to be tak

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Porous Scaffolds for Regeneration of Cartilage, Bone and Osteochondral Tissuefunctional tissues and organs. Various scaffolds have been prepared from biodegradable polymers and calcium phosphate. They have also been hybridized with bioactive factors to control differentiation of stem cells. Except the composition, porous structures of scaffolds are also extremely important f

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Layered Scaffolds for Osteochondral Tissue Engineeringeless, over the past decade great progress has been made to find suitables strategies towards OC regeneration. In the clinics, some osteochondral tissue engineering (OCTE) strategies have already been applied although with some incongruous outcomes as OC tissue is complex in its architecture and fun

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Preparation of Polymeric and Composite Scaffolds by 3D Bioprinting traditional used techniques for osteochondral regeneration remain to be inefficient since they cannot mimic the complexity of joint anatomy and tissue heterogeneity of articular cartilage. These limitations seem to be solved with the use of 3D bioprinting which can reproduce the anisotropic extrace

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Supercritical Fluid Technology as a Tool to Prepare Gradient Multifunctional Architectures Towards Rn of platelets from blood plasma. The possibility to use PLs as growth factor source for tissue healing and regeneration has been pursued following different strategies. Platelet lysates are an enriched pool of growth factors which can be used as either a GFs source or as a three-dimensional (3D) hy

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Gellan Gum-Based Hydrogels for Osteochondral Repair, and more recently in osteochondral TE approaches. Taking advantage of its inherent features such as biocompatibility, biodegradability, similarity with the extracellular matrix and easy functionalization, GG-based hydrogels have been studied for their potential for cartilage and bone tissue regene

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Silk Fibroin-Based Hydrogels and Scaffolds for Osteochondral Repair and Regenerationlage tissues, with long-term clinical outcomes. Hydrogels and scaffolds appeared as assertive approaches to guide the development and structure of the new osteochondral engineered tissue. Moreover, these structures alone or in combination with cells and bioactive molecules bring the mechanical suppo

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Natural Origin Materials for Osteochondral Tissue Engineeringextracellular matrix, the presence of cell recognition sites and tunable chemistry. However, the characteristics of natural origin materials can vary considerably depending on the specific source and extraction process. A deeper understanding of the relationship between material variability and biol