Titlebook: Organotypic Models in Drug Development; Monika Sch?fer-Korting,Silvya Stuchi Maria-Engler, Book 2021 Springer Nature Switzerland AG 2021 o

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Wolfram-Hubertus Zimmermannrmance and reliable solutions. At the end of this thorough and complex preliminary analysis the reader sees the true benefits and limitations of more traditional voltage control solutions, and gains an understa978-1-4471-7165-2978-1-4471-6636-8Series ISSN 1430-9491 Series E-ISSN 2193-1577

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Hans Christian Hennies,Yves Poumayalued functions, vector differential operators, tangent and normal vectors, straight lines, planes, intersections and rotating vectors. The new chapters are about the history, differentiating vector-valued func978-1-4471-7507-0978-1-4471-7505-6

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How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Developmentn morphology and drug target expression. Moreover, disease models differ from normal models in the expression of relevant biomarkers. As a result, qualified test methods can discriminate effects of treatment standards and the effects of weakly effective or ineffective substances. Observer-blind read

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In Vitro Models of the Blood-Brain Barrier for possible species differences. The blood-brain barrier is a dynamic, highly selective barrier formed by brain capillary endothelial cells. One of its main tasks is the maintenance of homeostasis in the CNS. The function of the barrier is regulated by cells of the microenvironment and the shear s

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Neural In Vitro Models for Studying Substances Acting on the Central Nervous Systemeuronal and mixed neuronal/astrocyte models, in vitro cultures of microglia, as well as CNS disease models and considers new developments in the field, more specifically the use of brain organoids and 3D bioprinted in vitro models for safety and efficacy evaluation.

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Disease Models: Lung Models for Testing Drugs Against Inflammation and Infectionting the essential hands-on techniques for the setup of in vitro models, we intend to combine these with already successful and interesting model approaches to serve as some guideline for the development of future models. The overall goal is to maximize time and cost-efficacy and to minimize attriti

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