Titlebook: Organometallics in Process Chemistry; Thomas J. Colacot,Vilvanathan Sivakumar Book 2019 Springer Nature Switzerland AG 2019 Organometallic

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Organometallic Approaches to [3.1.0] Bicycles in Process Chemistry,velopment, speed and flexibility are paramount, but as larger quantities of clinical candidates are required later in development, a route is typically chosen based on process robustness, product quality, and its overall efficiency with respect to several metrics. In this chapter we will highlight t

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Structural Diversity in Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation Reactions,rds the synthesis of biologically active molecules and natural products with high levels of diastereo- and enantioselectivity. This approach should be interesting to a large scientific community from both academic and industrial assets, and specially life-science businesses. Commercial supply of cat

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Meeting Metal Limits in Pharmaceutical Processes,ow chemists to be more inventive and efficient with their synthetic routes. More than 90% of chemicals involve the use of metal catalysts in their manufacture, yet the perceived challenge of metal removal can still be a deterrent to their use in the pharmaceutical industry. Any remaining metal can i

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Sodium Acrylate from Ethylene and CO2: The Path from Basic Research to a System Appropriate for a Ce by the oxidation of propene to acrylic acid followed by neutralization with NaOH. The synthesis of sodium acrylate from CO., ethylene, and NaOH would be very attractive due to lower raw material costs but was for many years only a “dream reaction.” Significant progress has been made since the firs

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Oxygen Effect in Heteromultimetallic Catalysis: Oxygen-Bridged Catalysts for Olefin Polymerization center can easily bind with a nucleophilic monomer and starts the polymerization process. With this objective in mind, we categorically designed and synthesized catalysts containing enhanced Lewis acidic metal centers of catalytically active metal centers with enhanced Lewis acidity. We have develop

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