Titlebook: Organic Acids in Man; Analytical Chemistry R. A. Chalmers,A. M. Lawson Book 1982 R. A. Chalmers and A. M. Lawson 1982 Alanin.amino acid.bio

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Extraction of organic acids from physiological fluidsprocess and with the preparation of protein-containing fluids for extraction. In addition the methods are discussed for the concentration of the extracted acids prior to derivative formation and gas chromatography or separation by other chromatographic systems.

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Organic acids in the study of metabolic diseasesake heavy demands on clinical resources. The study of the organic acidurias and of organic acids in man is therefore important, for the early diagnosis of disease, both prenatal, and postnatal in the newborn and infant (Fig. 9.1).

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ction established researchers in this field. The only previous text of the kind was the excellent review by Nordmann and Nordmann (1961), and at that time the main method of analysis was paper chromatography with liquid chromatography being used in a limited way. Only three diseases in which organic

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Specific causes of congenital keto acidosis in infantsdered to be identical enzymes. A report of a case of specific 3-oxoacyl-CoA thiolase deficiency has increased interest in these enzymes as causes of congenital keto acidosis, and these are discussed further below, as are patients with a different cause of a similar biochemical condition, succinyl-CoA:3-keto acid-CoA transferase deficiency.

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