Titlebook: Organ Directed Toxicities of Anticancer Drugs; Proceedings of the F Miles P. Hacker,John S. Lazo,Thomas R. Tritton Conference proceedings 1

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Role of Iron in Anthracycline Action direct evidence has not been presented which links iron chelation with the ability of this agent to prevent cardiac toxicity, this would have to be considered the leading hypothesis. Prior to these studies, it had been shown that the presence of iron could play and important role in doxorubicin-induced lipid peroxidation.

指耕作

Pulmonary Metabolic Inactivation of Bleomycin and Protection from Drug-Induced Lung Injury lipid peroxidation (1, 2). In this manuscript we will focus upon one major biochemical factor responsible for the preferential damage to the lungs: the lack of a protective enzyme called bleomycin hydrolase.

痛得哭了

怪物

Overviews in this section approach the problem from several perspectives, including both basic and applied science. Taken together, they provide a broad view of the underlying mechanisms and clinical ramifications associated with cardiotoxicity.

Obstruction

fleeting

A Trial of ICRF-187 to Selectively Protect Against Chronic Adriamycin Cardiac Toxicity: Rationale andule of administration have not substantially altered the antitumor activity. Further efforts in this area may yet bear fruit. However, at the present time the challenge to improve the therapeutic ratio must be met by reducing toxicity, particularly cardiac toxicity.

有危險

不法行為

Morose

預(yù)知