Titlebook: Oncogenes as Transcriptional Regulators; Retroviral Oncogenes M. Yaniv,J. Ghysdael Book 1997 Springer Basel AG 1997 Cancerogenese/Canceroge

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The v-erbA Oncogene,ukemia retrovirus. When injected intravenously into newborn chicks, it induces acute and fatal erythroleukemia. When injected sub-cutaneously it also induces sarcomas, but the erythroleukemia usually quickly takes over and kills the animal before the sarcoma has extended. This observation could also

MAOIS

Rel Proteins and Their Inhibitors: A Balancing Act,ole in integrating intra- and extracellular cues and assuring appropriate gene expression. The rel family of transcription factors, initially described as a DNA binding activity called NF-кB, mediate responses to a large number of stimuli in many cell types. These transcription factors are im

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Structure/Function and Oncogenic Conversion of Fos and Jun,erated by these stimuli invariably require a cellular response at the gene transcriptional level, which involves the functional mobilization of numerous transcription factors. The AP-1 transcription factor is a key player in mediating this environmental response.

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The v-erbA Oncogene,induces sarcomas, but the erythroleukemia usually quickly takes over and kills the animal before the sarcoma has extended. This observation could also explain that no other pathology has yet been described in chickens infected by AEV.

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, Proto-Oncogene Product as a Transcriptional Regulator,as demonstrated to function as a transcriptional activator that binds to specific DNA sequences. In this review, I shall address the structure of each functional domain in c-Myb, regulation of c-Myb activity, and mechanism of oncogenic activation of c-..