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Titlebook: Oncogenes Meet Metabolism; From Deregulated Gen G. Kroemer,D. Mumberg,K. Petersen Conference proceedings 2008 Springer-Verlag Berlin Heidel

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發(fā)表于 2025-3-21 19:01:23 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Oncogenes Meet Metabolism
副標(biāo)題From Deregulated Gen
編輯G. Kroemer,D. Mumberg,K. Petersen
視頻videohttp://file.papertrans.cn/702/701358/701358.mp4
叢書名稱Ernst Schering Foundation Symposium Proceedings
圖書封面Titlebook: Oncogenes Meet Metabolism; From Deregulated Gen G. Kroemer,D. Mumberg,K. Petersen Conference proceedings 2008 Springer-Verlag Berlin Heidel
描述.In 1920s, Otto Warburg described the phenomenon of ‘a(chǎn)erobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics)..
出版日期Conference proceedings 2008
關(guān)鍵詞Biomarkers; Cancer Research; Metabolic Profiling; Metabonomics; Warburg Effect; cells; diagnostics; physiol
版次1
doihttps://doi.org/10.1007/978-3-540-79478-3
isbn_softcover978-3-642-09840-6
isbn_ebook978-3-540-79478-3Series ISSN 0947-6075
issn_series 0947-6075
copyrightSpringer-Verlag Berlin Heidelberg 2008
The information of publication is updating

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發(fā)表于 2025-3-21 21:34:06 | 只看該作者
https://doi.org/10.1007/978-3-540-79478-3Biomarkers; Cancer Research; Metabolic Profiling; Metabonomics; Warburg Effect; cells; diagnostics; physiol
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Oncogenes Meet Metabolism978-3-540-79478-3Series ISSN 0947-6075
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Mitochondria and Cancer,brane permeabilization (MMP), which is the rate-limiting step of the intrinsic pathway of apoptosis. The mechanisms of MMP resistance have come under close scrutiny because apoptosis resistance constitutes one of the essential hallmarks of cancer. Second, cancer cell mitochondria often exhibit a?red
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Role of the Metabolic Stress Responses of Apoptosis and Autophagy in Tumor Suppression,that include insufficient nutrient supply caused by deficient angiogenesis and high metabolic demand of unrestrained cell proliferation. The high metabolic demand of tumor cells is only exacerbated by reliance on the inefficient process of glycolysis for energy production. Recently it has become cle
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The Interplay Between MYC and HIF in the Warburg Effect, MYC involves the induction of cell proliferation and enhancement of cellular metabolism, the function of HIF, particularly HIF-1, involves adaptation to the hypoxic microenvironment, including activation of anaerobic glycolysis. When MYC-dependent tumors grow, the hypoxic tumor microenvironment ele
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Using Metabolomics to Monitor Anticancer Drugs,tinue treatment or, in the context of a?drug trial, to indicate whether the drug is working and perhaps its mechanism of action. (Nuclear) magnetic resonance spectroscopy (NMR/MRS) methods can offer important insights into novel anticancer agents in order to accelerate the drug development process i
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