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Titlebook: Obesity and Breast Cancer; The Role of Dysregul Kristy A. Brown,Evan R. Simpson Book 2014 The Author(s) 2014 breast cancer.menopause.metabo

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發(fā)表于 2025-3-21 16:29:23 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Obesity and Breast Cancer
副標(biāo)題The Role of Dysregul
編輯Kristy A. Brown,Evan R. Simpson
視頻videohttp://file.papertrans.cn/701/700115/700115.mp4
概述Features cutting-edge aromatase research.Explores the application of novel therapies to inhibit aromatase in the breast.Discusses the connection between obesity and breast cancer in older women?.Inclu
叢書名稱SpringerBriefs in Cancer Research
圖書封面Titlebook: Obesity and Breast Cancer; The Role of Dysregul Kristy A. Brown,Evan R. Simpson Book 2014 The Author(s) 2014 breast cancer.menopause.metabo
描述Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters.?Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer.?Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in th
出版日期Book 2014
關(guān)鍵詞breast cancer; menopause; metabolism; obesity; oestrogen; metabolic disease
版次1
doihttps://doi.org/10.1007/978-1-4899-8002-1
isbn_softcover978-1-4899-8001-4
isbn_ebook978-1-4899-8002-1Series ISSN 2194-1173 Series E-ISSN 2194-1181
issn_series 2194-1173
copyrightThe Author(s) 2014
The information of publication is updating

書目名稱Obesity and Breast Cancer影響因子(影響力)




書目名稱Obesity and Breast Cancer影響因子(影響力)學(xué)科排名




書目名稱Obesity and Breast Cancer網(wǎng)絡(luò)公開度




書目名稱Obesity and Breast Cancer網(wǎng)絡(luò)公開度學(xué)科排名




書目名稱Obesity and Breast Cancer被引頻次




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Estrogen Biosynthesis,evels induce estrogen biosynthesis from granulosa cells of the developing follicles [80]. Estrogens produced from the ovaries act in an endocrine fashion to modulate gonadotrophin secretion, growth of the uterine lining, as well as maintain normal function of a wide range of tissues, including the b
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Estrogens, Adiposity and the Menopause,A woman’s reproductive years are characterized by finely tuned waves of circulating sex hormones which are dictated by her menstrual cycle and in turn, influence many, if not all, of her physiological functions.
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Therapy Aimed at Breaking the Linkage Between Obesity and Breast Cancer,Current endocrine therapy involving aromatase inhibitors is first line therapy for estrogen receptor positive breast cancer. Higher adiposity is associated with higher aromatase expression hence it has been hypothesized that endocrine therapy may not be as effective in overweight and obese individuals.
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SpringerBriefs in Cancer Researchhttp://image.papertrans.cn/o/image/700115.jpg
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