Titlebook: Neuroimmune Diseases; From Cells to the Li Hiroshi Mitoma,Mario Manto Reference work 2024Latest edition Springer Nature Switzerland AG 2024

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Significance of Autoantibodiesutoimmunity targeting brain proteins is enigmatic, because traditionally the central nervous system (CNS) is viewed as immune-privileged. However, the discovery of the lymphatic and glymphatic circulation in the CNS demonstrates the interaction between the CNS and the immune response. Furthermore, t

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Immune Tolerance in Autoimmune Central Nervous System Disordersns in the central nervous system, resulting in severely impaired signal transmission. The mechanisms of the induction and manifestation of MS are not entirely understood. The control of autoimmune disorders is accomplished by both central tolerance in which autoreactive T lymphocytes are eliminated

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Structural and Functional Characteristics of the Human Blood-Nerve Barrier with Translational Implicesponsible for structural integrity and the inner perineurium consisting of multiple concentric layers of specialized epithelioid myofibroblasts that surround the innermost endoneurium which consists of myelinated and unmyelinated axons embedded in a looser mesh of collagen fibers. Axons are respons

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Origin, Diversity, and Roles of Microgliabranching form in the healthy brain to a more dynamic, amoeboid shape when responding to pathological conditions. Acting as the brain’s resident macrophages, microglial cells swiftly react to injuries or invading pathogens. Recent research has shed light on their pivotal role in normal brain functio

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Autoimmune Astrocytopathyvely engage in various metabolic processes and are active contributors to immune responses within the CNS, with either beneficial or detrimental outcomes. The dynamic response of astrocytes to external signals leads to alterations in morphology, molecular expression, and function. In addition, auton

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The Intestinal Neuro-immune Axisex network of communication between the gut microbiota, immune cells, and the nervous system. Through this communication, the axis can orchestrate the response of the immune system to pathogens. The various neuropeptides, immune mediators, and neurotransmitters that are involved in this network play

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