Titlebook: Nucleic Acids and Molecular Biology; Fritz Eckstein,David M. J. Lilley Book 1993 Springer-Verlag Berlin Heidelberg 1993 DNA-Protein-Wechse

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殺蟲劑

Structural and Functional Aspects of the DNA Binding Protein FIS,t distant sites on DNA to approach each other or to facilitate interaction between proteins or protein and DNA sites that are located farther away along the DNA. The bending of DNA can be achieved either by certain base pair sequences (A-tracts) or, better, by DNA-binding proteins which stabilize a

affinity

異端

Resolution of Holliday Junctions by the , RuvC Protein, are two general questions regarding the mechanism by which Holliday junctions are resolved to form recombinant products: first, how is the junction recognized, and second, what are the biochemical mechanisms of the cleavage and ligation reactions. The recent identification of a Holliday junction-sp

博識

Site-Specific Recombination and the Segregation of Circular Chromosomes,on and excision of bacteriophage lambda into and out of the . chromosome (reviewed in Landy 1989). Subsequently, site-specific recombination has been shown to be involved in the integration/excision of many other viruses; in converting the initial products of replicative intermolecular transposition

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Nucleosome Positioning,on of nucleosomes along the DNA sequence, which may be important for transcription, replication, and other DNA transactions. Nucleosomes have been shown to occlude promoters and origins of replication, and to interfere with specific protein-binding to some regulatory sequences as well. The question

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The Role of the Nucleoskeleton in RNA Metabolism,y cells (Ivarie et al. 1983). This is to be compared with a 100-fold reduction in expression obtained by deleting promoters, enhancers or transcription-factor binding sites in plasmids prior to their transfection into tissue culture cells (Muller et al. 1988). Clearly, other important mechanisms mus

Conduit

The Mechanism of Action of the Retinoblastoma Gene Product,hood cancer, retinoblastoma (Knudson 1971). Since then, the Rb gene product (pRb) has established itself as a protein of central importance to those researchers interested in the regulation of cellular proliferation and the mechanisms of cellular transformation. Its biological properties do, however

小故事

Selection of Functional RNA and DNA Molecules from Randomized Sequences,erties (Green et al. 1991; Famulok and Szostak 1992b; Szostak 1992). Applications of this method include the evaluation of binding sites between proteins and double-stranded (ds) or single-stranded (ss) nucleic acids, the study of structure, function, and substrate specificity of ribozymes and the d

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